How it works
Delivers copper into cells and resets gene expression toward a younger profile, upregulating collagen, elastin and glycosaminoglycan synthesis while activating antioxidant defences and hair-follicle enlargement.
Structure: Tripeptide (Gly-His-Lys) with copper(II)
Reported benefits
- Increased collagen and elastin production
- Improved skin firmness and reduced fine lines
- Hair-follicle stimulation
- Accelerated wound healing
Practical considerations
- Topical formulations are the safest starting point
- Do not combine directly with vitamin C or strong acids in the same layer
- Injectable use can cause significant flushing and irritation
Side effects and risks
- Skin irritation or redness
- Copper accumulation with excessive systemic use
- Injection-site swelling
Dosing overview
Topical 1–3% serum daily; injectable protocols vary widely
This describes doses reported in published literature and community protocols. It is not a recommendation, and it is not a substitute for clinical supervision.
Research references
- Pickart & Margolina, 2018 — GHK-Cu regenerative and protective actions