How it works
Proposed to induce telomerase reverse transcriptase expression, allowing telomere elongation in somatic cells, and to normalise melatonin rhythm through pineal action.
Structure: Tetrapeptide (Ala-Glu-Asp-Gly)
Reported benefits
- Telomere lengthening reported in cell culture
- Improved sleep–wake rhythm
- Longevity signals in long-running Russian cohort studies
Practical considerations
- Key studies are decades old and largely unreplicated in the West
- Telomerase activation carries a theoretical oncogenic concern
- Usually run as short cycles two or three times per year
Side effects and risks
- Sparse safety data
- Occasional drowsiness
- Injection-site reaction
Dosing overview
5–10 mg daily for 10–20 days, cycled 1–3 times per year
This describes doses reported in published literature and community protocols. It is not a recommendation, and it is not a substitute for clinical supervision.
Research references
- Khavinson et al., 2003 — Epithalon and telomerase activity in human somatic cells