How it works
Acts as a ghrelin receptor (GHS-R1a) agonist on the pituitary, triggering a clean GH pulse. Its selectivity avoids the appetite and cortisol effects seen with older secretagogues like GHRP-6.
Structure: Pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2)
Reported benefits
- Clean GH pulse without hunger spikes
- Better sleep quality and recovery
- Mild fat-loss and body-composition support
Practical considerations
- Weakest GH release of the GHRPs — usually stacked with CJC-1295
- Effects build over weeks, not days
- Dose ceiling: more than ~300 mcg per pulse gives diminishing returns
Side effects and risks
- Mild headache
- Injection-site redness
- Light-headedness shortly after dosing
Dosing overview
200–300 mcg per dose, often 100–300 mcg before bed
This describes doses reported in published literature and community protocols. It is not a recommendation, and it is not a substitute for clinical supervision.
Research references
- Raun et al., 1998 — Ipamorelin, the first selective growth hormone secretagogue