How it works
Binds pituitary GHRH receptors to increase both the amplitude of GH pulses and total GH secretion. The DAC (drug affinity complex) version binds serum albumin, extending the half-life from minutes to about a week.
Structure: 30 amino acid GHRH analogue
Reported benefits
- Elevated GH and IGF-1 across the dosing window
- Improved sleep depth reported by most users
- Supports lean mass retention and fat oxidation
Practical considerations
- Usually paired with a GHRP such as Ipamorelin for a synergistic pulse
- No-DAC (Mod GRF 1-29) suits pulsatile dosing; DAC suits steady elevation
- GH elevation is not desirable for everyone — screen for cancer history
Side effects and risks
- Water retention
- Tingling or numbness in hands
- Head rush and flushing after injection
- Elevated fasting glucose at higher doses
Dosing overview
100 mcg (no-DAC) 1–3× daily, or 1–2 mg weekly for the DAC version
This describes doses reported in published literature and community protocols. It is not a recommendation, and it is not a substitute for clinical supervision.
Research references
- Teichman et al., 2006 — CJC-1295 pharmacokinetics in healthy adults