How it works
Binds KISS1R on GnRH neurons, stimulating pulsatile GnRH release and downstream LH and FSH secretion — the master switch of the hypothalamic–pituitary–gonadal axis.
Structure: Decapeptide fragment of kisspeptin
Reported benefits
- Increased LH and testosterone signalling
- Enhanced limbic response to sexual stimuli in imaging studies
- Fertility applications under investigation
Practical considerations
- Continuous exposure can desensitise the receptor — pulsatile use matters
- Human data comes from small imaging and endocrine studies
- Not a testosterone replacement
Side effects and risks
- Limited safety data
- Headache
- Possible hormonal disruption with chronic use
Dosing overview
Research doses vary; community use is typically low-microgram and infrequent
This describes doses reported in published literature and community protocols. It is not a recommendation, and it is not a substitute for clinical supervision.
Research references
- Comninos et al., 2017 — Kisspeptin modulates sexual and emotional brain processing