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Attribute
CategorySexual health
Evidence gradeEmerging
Also known asMetastin fragment 45-54
MechanismBinds KISS1R on GnRH neurons, stimulating pulsatile GnRH release and downstream LH and FSH secretion — the master switch of the hypothalamic–pituitary–gonadal axis.
Key benefitsIncreased LH and testosterone signalling · Enhanced limbic response to sexual stimuli in imaging studies · Fertility applications under investigation
Side effectsLimited safety data · Headache · Possible hormonal disruption with chronic use
Half-lifeUnder 30 minutes
AdministrationSubcutaneous injection
Dosing overviewResearch doses vary; community use is typically low-microgram and infrequent
StorageRefrigerated after reconstitution
Legal statusResearch chemical, not approved for human use.

Dosing figures reflect published literature and commonly reported community protocols. They are informational only.