How it works
A synthetic analogue of the immunopeptide tuftsin. It modulates GABA-A expression, inhibits enkephalin degradation and shifts the balance of monoamine neurotransmitters, producing calm without benzodiazepine-like sedation.
Structure: Heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro)
Reported benefits
- Anxiolytic effect without sedation or dependence
- Improved stress resilience
- Mild cognitive and immune modulation
Practical considerations
- Often paired with Semax for calm focus
- Western clinical evidence is minimal
- Effect size is modest
Side effects and risks
- Nasal irritation
- Occasional drowsiness
- Rare mood flattening
Dosing overview
250–750 mcg daily in divided doses, 2–4 week cycles
This describes doses reported in published literature and community protocols. It is not a recommendation, and it is not a substitute for clinical supervision.
Research references
- Zozulya et al., 2008 — Selank in generalised anxiety disorder