How it works
A non-hormonal ACTH fragment that raises BDNF and NGF expression in the hippocampus and modulates dopaminergic and serotonergic tone without corticotropic activity.
Structure: Heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro)
Reported benefits
- Increased BDNF signalling
- Improved attention and mental stamina
- Neuroprotective effects in ischaemia models
Practical considerations
- Nearly all clinical data is Russian-language
- Effects are subtle and cumulative
- Often cycled to avoid tolerance
Side effects and risks
- Nasal irritation
- Overstimulation or irritability
- Headache at higher doses
Dosing overview
300–600 mcg daily, split doses, in 2–4 week cycles
This describes doses reported in published literature and community protocols. It is not a recommendation, and it is not a substitute for clinical supervision.
Research references
- Kaplan et al., 1996 — Semax and cognitive function