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Attribute
CategoryMetabolic
Evidence gradeStrong
Also known asOzempic, Wegovy
MechanismMimics GLP-1 to enhance glucose-dependent insulin secretion, suppress glucagon, slow gastric emptying and act on hypothalamic appetite centres. Fatty-acid acylation extends its half-life to once-weekly dosing.
Key benefits~15% mean body-weight reduction over 68 weeks in STEP-1 · Improved HbA1c and cardiovascular outcomes · Marked reduction in appetite and food noise
Side effectsNausea and vomiting · Constipation or diarrhoea · Gallbladder issues · Contraindicated with medullary thyroid carcinoma history
Half-lifeAbout 7 days
AdministrationOnce-weekly subcutaneous injection (oral tablet also approved)
Dosing overviewLabel titration from 0.25 mg weekly up to 2.4 mg over 16+ weeks
StorageRefrigerate 2–8 °C; in-use pens may be kept at room temperature per label
Legal statusFDA-approved and prescription-only.

Dosing figures reflect published literature and commonly reported community protocols. They are informational only.