Comparison tool
Compare peptides
Pick up to three compounds. Useful for deciding whether two peptides in a stack actually do different things, or whether you're paying twice for the same pathway.
Select up to three (1/3)
Comparison results
| Attribute | |
|---|---|
| Category | Metabolic |
| Evidence grade | Strong |
| Also known as | Mounjaro, Zepbound |
| Mechanism | Activates both GIP and GLP-1 receptors. The added GIP activity appears to improve insulin sensitivity and lipid handling while blunting some of the nausea associated with pure GLP-1 agonism. |
| Key benefits | Up to ~21% mean weight loss at 15 mg in SURMOUNT-1 · Superior HbA1c reduction versus semaglutide in head-to-head trials · Improvements in sleep apnoea and blood pressure |
| Side effects | Nausea · Decreased appetite to the point of undereating · Diarrhoea · Rare pancreatitis |
| Half-life | About 5 days |
| Administration | Once-weekly subcutaneous injection |
| Dosing overview | 2.5 mg weekly starting dose, escalating in 2.5 mg steps up to 15 mg |
| Storage | Refrigerated pens; can be at room temperature for up to 21 days per label |
| Legal status | FDA-approved and prescription-only. |
Dosing figures reflect published literature and commonly reported community protocols. They are informational only.
Head-to-head comparisons
Each comparison below is its own page with the full attribute table, key differences and shared attributes for that pairing. They are grouped by the category the compounds are indexed under.
GLP-1 receptor agonists
Direct comparisons between the incretin-based compounds most often searched against one another.
Metabolic and GLP-1 compounds
Compounds indexed under metabolic use, including the GLP-1 receptor agonists and the smaller fat-metabolism peptides often searched alongside them.
Recovery and tissue repair
Pairings between compounds indexed for healing, connective tissue and post-injury recovery.
Growth-hormone axis
Secretagogues and releasing peptides that act on growth-hormone signalling, compared with each other and with adjacent compounds.
Longevity and mitochondrial
Compounds indexed under longevity, cellular and mitochondrial function.
Sexual health
Melanocortin and related compounds indexed for sexual-health use.