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Attribute
CategoryGrowth hormone
Evidence gradeModerate
Also known asModified GRF 1-29, DAC:GRF
MechanismBinds pituitary GHRH receptors to increase both the amplitude of GH pulses and total GH secretion. The DAC (drug affinity complex) version binds serum albumin, extending the half-life from minutes to about a week.
Key benefitsElevated GH and IGF-1 across the dosing window · Improved sleep depth reported by most users · Supports lean mass retention and fat oxidation
Side effectsWater retention · Tingling or numbness in hands · Head rush and flushing after injection · Elevated fasting glucose at higher doses
Half-life~30 minutes without DAC; ~6–8 days with DAC
AdministrationSubcutaneous injection, typically before bed on an empty stomach
Dosing overview100 mcg (no-DAC) 1–3× daily, or 1–2 mg weekly for the DAC version
StorageRefrigerate reconstituted product; protect from light and avoid shaking
Legal statusNot FDA-approved. Prescribed off-label by some clinics; banned in sport.

Dosing figures reflect published literature and commonly reported community protocols. They are informational only.