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Attribute
CategoryCognitive
Evidence gradeLimited
Also known asACTH(4-10) analogue
MechanismA non-hormonal ACTH fragment that raises BDNF and NGF expression in the hippocampus and modulates dopaminergic and serotonergic tone without corticotropic activity.
Key benefitsIncreased BDNF signalling · Improved attention and mental stamina · Neuroprotective effects in ischaemia models
Side effectsNasal irritation · Overstimulation or irritability · Headache at higher doses
Half-lifeMinutes intranasally; central effects persist for hours
AdministrationIntranasal spray or drops
Dosing overview300–600 mcg daily, split doses, in 2–4 week cycles
StorageRefrigerate the solution; discard per supplier guidance
Legal statusApproved medicine in Russia; unapproved elsewhere.

Dosing figures reflect published literature and commonly reported community protocols. They are informational only.